[Drug therapy in peripheral arterial occlusive disease].

Abstract

Drugs used for improvement or stabilization of peripheral circulation include antiaggregants or anticoagulants for secondary prevention of arteriosclerosis, vasoactive substances and fibrinolytic agents. -Two prospective trials document that aspirin or the combination of aspirin and dipyridamole reduce progression of arterial occlusive disease significantly in comparison to placebo. Aspirin is best suited for secondary prevention of recurrent stenoses or occlusions after carotid or femoral endarterectomy, whereas anticoagulants are preferred in patients with embolism and after peripheral implantation of venous bypasses. -Significant improvement of walking distance is achieved by several compounds influencing blood rheology. The effect does not exceed that obtained by physical training. If reconstructive arterial surgery or percutaneous transluminal angioplasty are not possible, some patients with rest pain or gangrene may be successfully treated by intraarterial administration of prostaglandin E1.

• Authors: A Bollinger
• Journal: Schweizerische medizinische Wochenschrift (Schweiz Med Wochenschr) Vol. 118 Issue 36 Pg. 1283-9 (Sep 10 1988) ISSN: 0036-7672 [Print] Switzerland
• Vernacular Title: Medikamentöse Therapie bei peripherer arterieller Verschlusskrankheit.
• PMID: 3051339 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Anticoagulants
• Fibrinolytic Agents
• Platelet Aggregation Inhibitors

Topics

• Anticoagulants (therapeutic use)
• Arterial Occlusive Diseases (drug therapy)
• Fibrinolytic Agents (therapeutic use)
• Humans
• Intermittent Claudication (drug therapy)
• Leg (blood supply)
• Platelet Aggregation Inhibitors (therapeutic use)
• Prospective Studies