HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Low-dose aspirin therapy improves fetal weight in umbilical placental insufficiency.

Abstract
A randomized, placebo-controlled, double-blind trial was carried out to evaluate the fetal benefits of low-dose aspirin (150 mg/day) as a treatment of placental insufficiency during the last trimester of pregnancy. Forty-six women referred for study because there was concern about fetal welfare were found to have an elevated umbilical artery wave form systolic/diastolic ratio. Mothers with severe hypertension were excluded because fetal condition would not necessarily be the dominant determinant of obstetric decision making. A distinction was made between a high systolic/diastolic ratio (greater than 95th but less than 99.95th percentile) and an extreme systolic/diastolic ratio (greater than 99.95th percentile). There were 34 patients in the high ratio group and 12 in the extreme group. Aspirin therapy was associated with an increase in birth weight (mean difference 526 gm [p less than 0.02]), head circumference (1.7 cm [p less than 0.025]), and placental weight (136 gm [p less than 0.02]) in those patients with a high initial umbilical artery systolic/diastolic ratio. For the 12 women with an extreme initial systolic/diastolic ratio, aspirin therapy did not result in a significantly different pregnancy outcome.
AuthorsB J Trudinger, C M Cook, R S Thompson, W B Giles, A Connelly
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 159 Issue 3 Pg. 681-5 (Sep 1988) ISSN: 0002-9378 [Print] United States
PMID3048102 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Aspirin
Topics
  • Adult
  • Aspirin (administration & dosage, therapeutic use)
  • Birth Weight (drug effects)
  • Blood Flow Velocity (drug effects)
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Fetal Growth Retardation (etiology, prevention & control)
  • Humans
  • Infant, Newborn
  • Organ Size (drug effects)
  • Placenta (drug effects, pathology)
  • Placenta Diseases (physiopathology)
  • Placental Insufficiency (complications, pathology, physiopathology)
  • Pregnancy
  • Random Allocation
  • Ultrasonography
  • Umbilical Arteries (drug effects, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: