Treatment of otitis media with cefuroxime axetil.

Abstract

Cefuroxime axetil and cefaclor were compared for efficacy in the treatment of acute otitis media with effusion. Sixty-four pediatric outpatients had tympanocentesis for culture, and then were randomized to a ten-day course of treatment with cefuroxime axetil or cefaclor. Streptococcus pneumoniae and Haemophilus influenzae were isolated from 25 (39%) and 23 (36%) patients, respectively. Treatment was beneficial in 26 (90%) of the patients who received cefuroxime axetil, and in 16 (76%) of the cefaclor-treated patients. Treatment failed in five (24%) of the cefaclor-treated patients, and in only three (10%) patients who received cefuroxime axetil. Haemophilus influenzae was the initial causative pathogen in a disproportionate number of treatment failures. This study demonstrates the efficacy of cefuroxime axetil in the treatment of otitis media.

• Authors: G H Aronovitz
• Journal: Southern medical journal (South Med J) Vol. 81 Issue 8 Pg. 978-80 (Aug 1988) ISSN: 0038-4348 [Print] United States
• PMID: 3043692 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Cephalosporins
• Pharmaceutical Preparations
• Prodrugs
• Cefaclor
• Cefuroxime
• cefuroxime axetil

Topics

• Acute Disease
• Cefaclor (administration & dosage, therapeutic use)
• Cefuroxime (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Cephalosporins
• Child
• Child, Preschool
• Clinical Trials as Topic
• Drug Administration Schedule
• Drug Evaluation
• Female
• Humans
• Infant
• Male
• Otitis Media with Effusion (complications, drug therapy)
• Pharmaceutical Preparations (administration & dosage)
• Prodrugs (administration & dosage, adverse effects)
• Random Allocation