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Phenotypic, cytogenetic and molecular characterization of a new B-chronic lymphocytic leukaemia (B-CLL) cell line.

Abstract
A lymphoid cell line was established from a patient with B-cell chronic lymphocytic leukaemia (B-CLL) by infecting blood lymphocytes with Epstein-Barr virus (EBV). Immunoglobulin gene rearrangement studies and the presence of a chromosome marker (isochromosome 17q) provided the formal proof that the line has originated from the neoplastic B cells. The morphology and phenotype indicate that the EBV-induced cell line has reached a plasma cell-like stage of differentiation.
AuthorsF Caligaris-Cappio, L Bergui, G Rege-Cambrin, L Tesio, N Migone, F Malavasi
JournalLeukemia research (Leuk Res) Vol. 11 Issue 7 Pg. 579-88 ( 1987) ISSN: 0145-2126 [Print] England
PMID3039258 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Genetic Markers
  • Immunoglobulins
Topics
  • B-Lymphocytes
  • Cell Differentiation
  • Cell Line
  • Cell Transformation, Viral
  • Chromosomes, Human, Pair 17 (ultrastructure)
  • Genetic Markers
  • Herpesvirus 4, Human
  • Humans
  • Immunoglobulins (genetics)
  • Leukemia, Lymphoid (genetics, pathology)
  • Male
  • Middle Aged
  • Phenotype
  • Plasma Cells (pathology)

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