Abstract |
A lymphoid cell line was established from a patient with B-cell chronic lymphocytic leukaemia (B-CLL) by infecting blood lymphocytes with Epstein-Barr virus (EBV). Immunoglobulin gene rearrangement studies and the presence of a chromosome marker ( isochromosome 17q) provided the formal proof that the line has originated from the neoplastic B cells. The morphology and phenotype indicate that the EBV-induced cell line has reached a plasma cell-like stage of differentiation.
|
Authors | F Caligaris-Cappio, L Bergui, G Rege-Cambrin, L Tesio, N Migone, F Malavasi |
Journal | Leukemia research
(Leuk Res)
Vol. 11
Issue 7
Pg. 579-88
( 1987)
ISSN: 0145-2126 [Print] England |
PMID | 3039258
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Genetic Markers
- Immunoglobulins
|
Topics |
- B-Lymphocytes
- Cell Differentiation
- Cell Line
- Cell Transformation, Viral
- Chromosomes, Human, Pair 17
(ultrastructure)
- Genetic Markers
- Herpesvirus 4, Human
- Humans
- Immunoglobulins
(genetics)
- Leukemia, Lymphoid
(genetics, pathology)
- Male
- Middle Aged
- Phenotype
- Plasma Cells
(pathology)
|