Abstract |
We reported previously that DN-1417, a potent analog of thyrotropin-releasing hormone (TRH), suppressed both the progression of amygdaloid (AM) kindling and AM kindled seizure. To study a functional role of the cerebral TRH mechanism in AM kindling, immunoreactive TRH (IR-TRH) and specific TRH receptor binding were examined in the rat brains kindled from the left AM. The IR-TRH concentration elevated significantly in the amygdala plus piriform cortex and the hippocampus 24 and 48 hours after the AM kindled convulsion. Such an elevation of IR-TRH was not found 7 days after the last convulsion, indicating that the elevation of IR-TRH was a transient change seen after the AM kindled convulsion. By contrast, the specific TRH receptor binding in the striatum increased 48 hours, 7 and 21 days after the AM kindled convulsion. This indicates that the increase of the specific TRH binding in the striatum was a long-lasting change. The present study suggests that the change in the striatal TRH receptors may be associated with a long-lasting seizure susceptibility of AM kindled rats.
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Authors | S Kajita, M Nakashima, M Okamoto, M Sato, N Ogawa |
Journal | The Japanese journal of psychiatry and neurology
(Jpn J Psychiatry Neurol)
Vol. 40
Issue 3
Pg. 345-7
(Sep 1986)
ISSN: 0912-2036 [Print] Japan |
PMID | 3033370
(Publication Type: Journal Article)
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Chemical References |
- Receptors, Neurotransmitter
- Receptors, Thyrotropin-Releasing Hormone
- Thyrotropin-Releasing Hormone
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Topics |
- Amygdala
(physiology)
- Animals
- Biomechanical Phenomena
- Brain
(metabolism)
- Kindling, Neurologic
- Male
- Radioimmunoassay
- Rats
- Rats, Inbred Strains
- Receptors, Neurotransmitter
(metabolism)
- Receptors, Thyrotropin-Releasing Hormone
- Thyrotropin-Releasing Hormone
(metabolism)
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