Polymeric albumin in the urine of patients with nephrotic syndrome.

Abstract

Dimer and polymer albumin was detected in the urine of a proportion of pantients with a nephrotic syndrome. Most of it was present as S-S bonded dimer and polymer; co-polymers, however, with IgG and alpha (1) anti-trypsin could be demonstrated. It is suggested that albumin polymerizes after it has passed the glomerular membrane. Albumin dimer was associated mainly with minimal change disease and early membranous glomerulopathy in patients, who in general responded well to therapy.

• Authors: W H Boesken, F Schindera, M Billingham, J Hardwicke, R H White, A Williams
• Journal: Clinical nephrology (Clin Nephrol) Vol. 8 Issue 3 Pg. 395-9 (Sep 1977) ISSN: 0301-0430 [Print] Germany
• PMID: 303162 (Publication Type: Journal Article)

Chemical References

• Albumins
• Immunoglobulin G
• Polymers
• Serum Albumin
• alpha 1-Antitrypsin
• Cyclophosphamide
• Prednisolone

Topics

• Albumins (metabolism)
• Albuminuria
• Cyclophosphamide (therapeutic use)
• Electrophoresis, Polyacrylamide Gel
• Humans
• Immunoglobulin G (analysis, metabolism)
• Kidney Glomerulus (metabolism)
• Molecular Weight
• Nephrotic Syndrome (blood, drug therapy, metabolism, urine)
• Polymers (metabolism)
• Prednisolone (therapeutic use)
• Serum Albumin (analysis)
• alpha 1-Antitrypsin (metabolism)