Chemotherapy for gestational trophoblastic tumors.

Abstract

Virtually 100% of patients with nonmetastatic and low-risk metastatic trophoblastic tumors are now curable by only conventional chemotherapeutic agents such as methotrexate, actinomycin D, or their combination with or without other agents. However, approximately 30% of high-risk patients with metastatic trophoblastic tumors are resistant to conventional chemotherapy. All of the high-risk patients resistant to chemotherapy are those with metastatic choriocarcinoma. Thus, the efficacy of multidrug chemotherapy and combination chemotherapy of cisplatin or VP16-213 with other agents is now being examined.

• Authors: H Takamizawa, S Sekiya, O Kobayashi, H Matsui
• Journal: Seminars in surgical oncology (Semin Surg Oncol) Vol. 3 Issue 1 Pg. 36-44 ( 1987) ISSN: 8756-0437 [Print] United States
• PMID: 3027827 (Publication Type: Journal Article)

Chemical References

• Chorionic Gonadotropin
• Chlorambucil
• Dactinomycin
• Etoposide
• Luteinizing Hormone
• Cisplatin
• Methotrexate

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chlorambucil (administration & dosage)
• Choriocarcinoma (drug therapy)
• Chorionic Gonadotropin (blood, urine)
• Cisplatin (administration & dosage)
• Dactinomycin (administration & dosage)
• Drug Administration Schedule
• Drug Resistance
• Etoposide (administration & dosage)
• Female
• Humans
• Hydatidiform Mole (drug therapy)
• Luteinizing Hormone (blood)
• Methotrexate (administration & dosage)
• Neoplasm Metastasis
• Neoplasm Recurrence, Local (drug therapy)
• Pregnancy
• Pregnancy Complications, Neoplastic (drug therapy)
• Prognosis
• Trophoblastic Neoplasms (drug therapy)
• Uterine Neoplasms (drug therapy)