HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Cushing's disease in a young woman with anorexia nervosa: pathophysiological implications.

Abstract
This report describes a 17-year old student who was found to have Cushing's syndrome two years after she had developed anorexia nervosa (AN). The Cushing's syndrome was treated with bilateral resection of enlarged, hyperplastic, non-tumorous adrenal glands. The diagnosis was further confirmed four years later when, two to three years after new symptoms had appeared, an ACTH secreting pituitary adenoma (that is, Cushing's disease) was found on surgery. The possible mechanism for the development of Cushing's disease in a patient with prior anorexia nervosa, a sequence of events reported once previously, is discussed. It is suggested that increased hypothalamic-pituitary corticotroph stimulation in association with the anorexia nervosa, a now well-established endocrine phenomenon, activated an occult, inactive pituitary basophil adenoma in this patient, eventually resulting in autonomous pituitary overproduction of ACTH by the tumor.
AuthorsJ L Katz, H Weiner, J Kream, B Zumoff
JournalCanadian journal of psychiatry. Revue canadienne de psychiatrie (Can J Psychiatry) Vol. 31 Issue 9 Pg. 861-4 (Dec 1986) ISSN: 0706-7437 [Print] CANADA
PMID3026602 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Adrenocorticotropic Hormone
  • Hydrocortisone
Topics
  • Adenoma, Basophil (complications, secretion)
  • Adolescent
  • Adrenocorticotropic Hormone (secretion)
  • Anorexia Nervosa (complications, physiopathology)
  • Cushing Syndrome (complications, physiopathology)
  • Female
  • Humans
  • Hydrocortisone (blood)
  • Pituitary Neoplasms (complications, secretion)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: