[A case report of patient with advanced stomach carcinoma of linitis plastica type responding to multi-immunotherapy and chemotherapy].

Abstract

Multiple-drug (OK-432, PSK and SPG) immunotherapy and chemotherapy provided remission of symptoms for 36 months in a patient aged 21 years suffering scirrhous gastric carcinoma associated with carcinomatous peritonitis in which direct infiltration to the pancreas, retroperitoneum and the left colon was observed. A remarkable improvement with time was observed by endoscopic and roentgenographic observation, and a substantial improvement was also observed in the NK-cell ratios of lymphocyte subsets of the OKT series in relation to immunologic parameters. A tumor necrosis factor [TNF]-like substance was thought to have been induced by multiimmunotherapy in this case.

• Authors: A Yagita, I Orima, N Okada, S Ootsuka, T Oda, N Takeuchi, N Hosaka, H Matsumoto, H Itoh, M Ono
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 14 Issue 1 Pg. 196-9 (Jan 1987) ISSN: 0385-0684 [Print] Japan
• PMID: 3026254 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biological Products
• Glycosaminoglycans
• Mitomycins
• Proteoglycans
• Carbazilquinone
• Picibanil
• polysaccharide-K
• Mitomycin
• Sizofiran

Topics

• Adenocarcinoma, Scirrhous (drug therapy)
• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biological Products (administration & dosage)
• Carbazilquinone (administration & dosage)
• Glycosaminoglycans (administration & dosage)
• Humans
• Male
• Mitomycin
• Mitomycins (administration & dosage)
• Picibanil (administration & dosage)
• Proteoglycans (administration & dosage)
• Sizofiran (administration & dosage)
• Stomach Neoplasms (drug therapy)