Short term administration of potassium perchlorate restores euthyroidism in amiodarone iodine-induced hypothyroidism.

Abstract

We studied the effect of potassium perchlorate (KClO4) in patients with hypothyroidism due to amiodarone. The short term administration of KClO4 to six such patients led to prompt restoration of euthyroidism, while the three untreated patients remained hypothyroid for 2-6 months. Since KClO4 inhibits thyroid iodide transport, thereby blocking further entrance of iodide into the thyroid and decreasing intrathyroidal iodide content, amiodarone-associated hypothyroidism is probably secondary to the inhibitory effect of excess intrathyroidal iodine on thyroid hormone synthesis.

• Authors: E Martino, S Mariotti, F Aghini-Lombardi, M Lenziardi, S Morabito, L Baschieri, A Pinchera, L Braverman, M Safran
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 63 Issue 5 Pg. 1233-6 (Nov 1986) ISSN: 0021-972X [Print] United States
• PMID: 3020079 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Perchlorates
• Potassium Compounds
• potassium perchlorate
• Thyrotropin
• Amiodarone
• Thyroxine
• Potassium

Topics

• Adult
• Aged
• Aged, 80 and over
• Amiodarone (adverse effects)
• Female
• Humans
• Hypothyroidism (blood, chemically induced, drug therapy)
• Male
• Middle Aged
• Perchlorates (administration & dosage)
• Potassium (administration & dosage)
• Potassium Compounds
• Thyrotropin (blood)
• Thyroxine (blood)
• Time Factors