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Treatment of acid-peptic diseases by inhibition of gastric H+,K+-ATPase.

Abstract
The substituted benzimidazoles are a new class of drugs with a unique antisecretory action. These agents have great potential for treatment of acid-peptic disease because they produce substantial, long-lasting inhibition of gastric acid secretion by inhibiting gastric H+,K+-ATPase in the gastric parietal cell. Clinical trials of omeprazole, a substituted benzimidazole, indicate that it is safe and effective for short-term treatment of patients with duodenal or gastric ulcer, and it is highly effective for long-term treatment of patients with Zollinger-Ellison syndrome.
AuthorsK E McArthur, R T Jensen, J D Gardner
JournalAnnual review of medicine (Annu Rev Med) Vol. 37 Pg. 97-105 ( 1986) ISSN: 0066-4219 [Print] United States
PMID3010811 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • Benzimidazoles
  • Adenosine Triphosphatases
  • H(+)-K(+)-Exchanging ATPase
  • Omeprazole
Topics
  • Adenosine Triphosphatases (antagonists & inhibitors)
  • Anti-Ulcer Agents (administration & dosage, adverse effects, therapeutic use)
  • Benzimidazoles (administration & dosage, adverse effects, therapeutic use)
  • Clinical Trials as Topic
  • Duodenal Ulcer (drug therapy)
  • Gastric Acid (metabolism)
  • H(+)-K(+)-Exchanging ATPase
  • Humans
  • Omeprazole
  • Parietal Cells, Gastric (enzymology)
  • Peptic Ulcer (drug therapy)
  • Stomach Ulcer (drug therapy)
  • Zollinger-Ellison Syndrome (drug therapy)

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