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Antiviral therapy for cytomegalovirus retinitis in AIDS with dihydroxy propoxymethyl guanine.

Abstract
Six patients (all male, five homosexual and one bisexual, 23 to 48 years old) with the acquired immune deficiency syndrome (AIDS) who had cytomegalovirus retinitis were treated with a new antiviral drug as a part of a prospective open-labeled trial for serious cytomegalovirus infections. The drug, 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl] guanine (referred to as dihydroxy propoxymethyl guanine), a new acyclic nucleoside antiviral agent similar in structure to acyclovir, produced positive results. These patients treated with dihydroxy propoxymethyl guanine (2.5 mg/kg of body weight every eight hours) showed regression and often disappearance of the lesions of cytomegalovirus retinitis during and for several weeks after therapy, usually with concomitant resolution of viral shedding. The cytomegalovirus retinitis recurred in four patients (the other two were lost to follow-up), but retreatment usually led to remission. Adverse drug toxicity (reversible granulocytopenia) occurred in two patients.
AuthorsL R Rosecan, C M Stahl-Bayliss, C M Kalman, O L Laskin
JournalAmerican journal of ophthalmology (Am J Ophthalmol) Vol. 101 Issue 4 Pg. 405-18 (Apr 15 1986) ISSN: 0002-9394 [Print] United States
PMID3008560 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiviral Agents
  • Ganciclovir
  • Acyclovir
Topics
  • Acquired Immunodeficiency Syndrome (drug therapy, pathology)
  • Acyclovir (analogs & derivatives, therapeutic use)
  • Adult
  • Antiviral Agents (therapeutic use)
  • Cytomegalovirus Infections (drug therapy, pathology)
  • Ganciclovir
  • Humans
  • Male
  • Middle Aged
  • Retinitis (drug therapy, pathology)

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