Distribution of type D retrovirus sequences in tissues of macaques with simian acquired immune deficiency and retroperitoneal fibromatosis.

Abstract

Horizontally acquired SAIDS retrovirus type 2 (SRV-2), a type D retrovirus related to the Mason-Pfizer monkey virus, has been associated with the simian acquired immunodeficiency syndrome (SAIDS) including retroperitoneal fibromatosis (RF) in several macaque species at two primate research centers. Virus specific gene sequences are present in lymphoid and RF tissues but not in muscle tissue of diseased macaques or in any tissues of uninfected normal monkeys. Serologic and restriction endonuclease mapping techniques have defined unique SRV-2 strains in the Celebes (SRV-2C) and rhesus (SRV-2R) macaques at the Oregon Regional Primate Center, SRV-2 is related to both MPMV and SAIDS type 1 retroviruses and it has no detectable molecular homology with the human AIDS retroviruses.

• Authors: M L Bryant, P A Marx, S M Shiigi, B J Wilson, W P McNulty, M B Gardner
• Journal: Virology (Virology) Vol. 150 Issue 1 Pg. 149-60 (Apr 15 1986) ISSN: 0042-6822 [Print] United States
• PMID: 3006332 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA, Viral
• DNA Restriction Enzymes

Topics

• Acquired Immunodeficiency Syndrome (microbiology, veterinary)
• Animals
• Cloning, Molecular
• DNA Restriction Enzymes
• DNA, Viral (analysis)
• Macaca (microbiology)
• Retroperitoneal Fibrosis (microbiology, veterinary)
• Retroviridae (genetics)
• Sequence Homology, Nucleic Acid