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The influence of Bordetella pertussis and its constituents on the beta-adrenergic receptor in the guinea pig respiratory system.

Abstract
In the present study, the effect of vaccination of guinea pigs with Bordetella pertussis was investigated, 4 days after treatment, on the cholinergic and beta-adrenergic receptor function in isolated tracheal spirals and the number of beta-adrenoceptor binding sites in guinea pig lung. It was found that B. pertussis caused an impairment in the beta-adrenoceptor function and a decrease in its number. Similar results were obtained with endotoxin. Leucocytosis promoting factor, however, was ineffective. These results indicate that endotoxin is the constituent responsible for the beta-adrenoceptor blocking effects of the bacterium. Also the combined whole cell diphtheria, B. pertussis and tetanus toxoid vaccine induced a beta-adrenoceptor blockade; the acellular vaccine was less effective. The results obtained with the B. pertussis vaccines are discussed in relation to the possible side-effects that sometimes occur after immunization of infants.
AuthorsD van Heuven-Nolsen, G Folkerts, D J de Wildt, F P Nijkamp
JournalLife sciences (Life Sci) Vol. 38 Issue 8 Pg. 677-85 (Feb 24 1986) ISSN: 0024-3205 [Print] Netherlands
PMID3005792 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Endotoxins
  • Pertussis Vaccine
  • Receptors, Adrenergic, beta
  • Tetanus Toxoid
  • Carbachol
  • Isoproterenol
  • Norepinephrine
  • Epinephrine
Topics
  • Animals
  • Carbachol (pharmacology)
  • Endotoxins (pharmacology)
  • Epinephrine (metabolism)
  • Guinea Pigs
  • Isoproterenol (pharmacology)
  • Lung (physiology)
  • Male
  • Muscle Contraction (drug effects)
  • Muscle Relaxation (drug effects)
  • Norepinephrine (metabolism)
  • Pertussis Vaccine (pharmacology)
  • Receptors, Adrenergic, beta (physiology)
  • Tetanus Toxoid (pharmacology)
  • Tissue Distribution
  • Trachea (physiology)

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