Abstract |
The effect of acrylamide and six analogues on glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and enolase in sciatic nerve was examined in rats after their prolonged administration in drinking water. After 15 days' treatment with acrylamide and N-isopropylacrylamide, slight signs of peripheral neuropathy were produced with no changes in the activity of either enzyme. N,N-dimethylacrylamide, a non-neurotoxic analogue, produced only body weight loss at this stage. After 30 days' treatment, acrylamide and N-isopropylacrylamide produced moderate signs of neuropathy, but no changes in enzyme activity. N,N-dimethylacrylamide produced a reduction in GAPDH activity as well as body weight loss. After 45 days' treatment, acrylamide, N-isopropylacrylamide, N-hydroxymethylacrylamide and N-methylacrylamide produced severe signs of neuropathy as well as body weight loss. All these analogues also produced a reduction in the two enzyme activities, except for enolase after N-isopropylacrylamide. N,N-dimethylacrylamide produced inhibition of GAPDH as well as body weight loss without neuropathy. N- tert-butylacrylamide and N,N'-methylene-bis-acrylamide induced neither neuropathy nor inhibition of either enzyme.
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Authors | J Sakamoto, K Hashimoto |
Journal | Archives of toxicology
(Arch Toxicol)
Vol. 57
Issue 4
Pg. 282-4
(Sep 1985)
ISSN: 0340-5761 [Print] Germany |
PMID | 3004383
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acrylamides
- Glyceraldehyde-3-Phosphate Dehydrogenases
- Phosphopyruvate Hydratase
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Topics |
- Acrylamides
(toxicity)
- Animals
- Glyceraldehyde-3-Phosphate Dehydrogenases
(metabolism)
- Glycolysis
(drug effects)
- Male
- Peripheral Nervous System Diseases
(chemically induced)
- Phosphopyruvate Hydratase
(metabolism)
- Rats
- Rats, Inbred Strains
- Sciatic Nerve
(enzymology)
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