Abstract |
The authors presented the results of a study of the level of corticotropin and cortisol in the blood at different time after a single intake of peritol or parlodel in 48 patients with Icenko- Cushing disease at the active stage. Corticotropin and cortisol concentrations were determined by radioimmunoassay with the help of standard kits. The study showed a different sensitivity of patients with Icenko- Cushing disease to peritol and parlodel. According to the expression of the reaction of the hypophyseal-adrenal system all the patients were divided into the following groups: with a noticeable reaction to one or both drugs, with a slightly noticeable decrease in the level of hormones or a paradoxical reaction to the drugs. A single test with inhibitors of hypophyseal corticotropic function provided an opportunity for an individual choice of an effective drug for pathogenetic treatment of patients with Icenko- Cushing disease. The optimum time for blood examination to determine the concentration of corticotropin was 1 and 2 hrs, the level of cortisol 2-4 hrs after the intake of peritol and parlodel.
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Authors | V N Slavnov, E V Luchitskiĭ, A K Cheban |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 57
Issue 12
Pg. 36-9
( 1985)
ISSN: 0040-3660 [Print] Russia (Federation) |
Vernacular Title | Kriterii vybora preparata dlia patogeneticheskogo lecheniia bolezni Itsenko-Kushinga. |
PMID | 3003946
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Cyproheptadine
- Bromocriptine
- Adrenocorticotropic Hormone
- Hydrocortisone
|
Topics |
- Adrenocorticotropic Hormone
(metabolism)
- Adult
- Bromocriptine
(therapeutic use)
- Clinical Trials as Topic
- Cushing Syndrome
(drug therapy, etiology)
- Cyproheptadine
(therapeutic use)
- Female
- Follow-Up Studies
- Humans
- Hydrocortisone
(metabolism)
- Male
- Middle Aged
- Pituitary-Adrenal System
(metabolism)
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