The effect of dietary bagasse on the activities of some key enzymes of carbohydrate and lipid metabolism in mouse liver.

The effects of a 100 g/kg diet substitution of bagasse on the body-weight gain, food consumption and faecal dry weight of mice given a high-sucrose diet and on the activities of hepatic glucose-6-phosphate dehydrogenase (EC I.I.I.49), 6-phosphogluconate dehydrogenase (EC I.I.I.44), malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) (EC I.I.I.40), ATP-citrate (pro-3S) lyase (EC 4.I.3.8), 6-phosphofructokinase EC 2.7.I.II), pyruvate kinase (EC 2.7.I.40) and fructose-1,6-bisphosphatase (EC 3.I.3.II) were studied. Bagasse had no effect on body-weight gain, food consumption or faecal dry weight. Bagasse decreased the activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and phosphofructokinase expressed on a wet weight basis and on a protein basis. Bagasse decreased the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase expressed on a body-weight basis. These results suggest that bagasse decreases the flux through some pathways of hepatic lipogenesis when mice are given high-sucrose diets.
AuthorsJ C Stanley, E A Newsholme
JournalThe British journal of nutrition (Br J Nutr) Vol. 54 Issue 2 Pg. 415-20 (Sep 1985) ISSN: 0007-1145 [Print] ENGLAND
PMID2998453 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • NADP
  • Cellulose
  • bagasse
  • Animals
  • Body Weight
  • Carbohydrate Metabolism
  • Cellulose (pharmacology)
  • Dietary Fiber (pharmacology)
  • Eating
  • Feces
  • Lipid Metabolism
  • Liver (enzymology)
  • Mice
  • NADP (metabolism)

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