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Osteomas in OF-1 mice: no alteration in biologic behavior during long-term treatment with cyclosporine.

Abstract
During the course of a long-term oral study in OF-1 mice for the assessment of any carcinogenic potential of the immunosuppressive agent cyclosporine (CS-A), a high incidence of osteomas was found in all treatment groups as well as in controls. The incidences of osteoma-bearing mice were 20% in control male and 30% in control female mice; the respective incidences in all treated mice were 14.7% for males and 38% for females. The osteomas were found to occur in multiple sites in 70% of control males, in 73.3% of control females, and from all treated groups in 54.5% of males and 64.9% of females. The pelvis and sacrum were most frequently involved (42%), followed by the hindlimbs (32%), the skull (14.5%), the vertebral column (6.5%), the forelimbs (4%), and the sternum and ribs (1%) in control animals. The distribution of osteomas was similar in treated mice and did not differ significantly from controls. Histologic and ultrastructural analysis confirmed benign osteomas with abundant C-type viral particles. Thus a previously unobserved spontaneous high incidence of osteomas was reported in OF-1 mice. Immunosuppressive treatment with CS-A did not change the incidence or the biologic behavior of these osteomas.
AuthorsJ T Wilson, R E Hauser, B Ryffel
JournalJournal of the National Cancer Institute (J Natl Cancer Inst) Vol. 75 Issue 5 Pg. 897-903 (Nov 1985) ISSN: 0027-8874 [Print] United States
PMID2997534 (Publication Type: Journal Article)
Chemical References
  • Cyclosporins
Topics
  • Animals
  • Bone Neoplasms (chemically induced)
  • Cyclosporins (toxicity)
  • Female
  • Herpesvirus 4, Human (pathogenicity)
  • Lymphoma (chemically induced)
  • Male
  • Mice
  • Mice, Inbred Strains
  • Osteoma (chemically induced)
  • Sex Factors

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