[Effect of TRH and its analog DN-1417 on anoxia-induced amnesia in mice].

Abstract

The effect of neuropeptides and their analogs on anoxia-induced amnesia was examined using one-trial passive avoidance task in mice. Anoxia, produced by the exposure to CO2 immediately after the acquisition of avoidance response, induced amnesia which is shown by a short latency to enter from the safety compartment into the shocked compartment in the retention test conducted 24 hr later. In these anoxia-treated animals, thyrotropin-releasing hormone (TRH: 10-20 mg/kg), its analog DN-1417 (10-20 mg/kg) and ACTH 4-10 (66 micrograms/body), which were given sc 15-60 min before the retention test, markedly prolonged the latency in a dose-dependent manner, indicating a reversal of the amnesia. Arginine- and lysine-vasopressin also reversed the amnesia at a dose of 100 micrograms/body. These results suggest that TRH and DN-1417, known to reverse the amnesia produced by the protein synthesis inhibitor cycloheximide, have ameliorating effects on the retrieval process of memory.

• Authors: N Yamazaki, M Shintani, Y Saji, Y Nagawa
• Journal: Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology (Yakubutsu Seishin Kodo) Vol. 5 Issue 1 Pg. 1-9 (May 1985) ISSN: 0285-5313 [Print] Japan
• PMID: 2996254 (Publication Type: Journal Article)

Chemical References

• Vasopressins
• Thyrotropin-Releasing Hormone
• Adrenocorticotropic Hormone
• DN 1417

Topics

• Adrenocorticotropic Hormone (therapeutic use)
• Amnesia (drug therapy, etiology)
• Animals
• Hypoxia (complications)
• Male
• Memory (drug effects)
• Mice
• Thyrotropin-Releasing Hormone (analogs & derivatives, therapeutic use)
• Vasopressins (therapeutic use)