Abstract |
Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus titre and slight prolongation of survival. Acyclovir (ACV) and dihydroxypropoxymethylguanine ( DHPG) were both less active than BVDU when tested against the virus in BHK cells, yet DHPG therapy was extremely effective in mice; it reduced virus titres markedly and resulted in the long-term survival of mice given a potentially lethal infection. When ACV and DHPG were tested in vitro using murine rather than hamster cells, these compounds, especially DHPG, were shown to be much more active against PRV.
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Authors | H J Field |
Journal | Antiviral research
(Antiviral Res)
Vol. 5
Issue 3
Pg. 157-68
(Jun 1985)
ISSN: 0166-3542 [Print] Netherlands |
PMID | 2992370
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- brivudine
- Bromodeoxyuridine
- Ganciclovir
- Acyclovir
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Topics |
- Acyclovir
(analogs & derivatives, pharmacology, therapeutic use)
- Animals
- Antiviral Agents
(pharmacology, therapeutic use)
- Bromodeoxyuridine
(analogs & derivatives, pharmacology, therapeutic use)
- Cell Line
- Cells, Cultured
- Cricetinae
- Female
- Ganciclovir
- Herpesvirus 1, Suid
(drug effects)
- Mice
- Mice, Inbred BALB C
- Pruritus
(drug therapy)
- Pseudorabies
(drug therapy)
- Time Factors
- Viral Plaque Assay
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