Visual evoked potentials as a predictor of reported side effects during a trial of zimelidine vs. placebo in chronic pain patients.

Before a double-blind controlled study of zimelidine, a new, rather specific inhibitor of serotonin uptake, in patients with chronic pain, visual evoked potentials (EPs) to stimuli of varying intensities were recorded. During the trial the blood levels of zimelidine and its active metabolite norzimelidine were estimated. Side effects were rated by a physician before and after the trial. No significant difference in frequency of side effects could be found between the zimelidine and the placebo groups. Furthermore, there was no significant relationship between the blood levels of the active drug or its metabolite and the frequency of side effects. Instead, a significant relationship was found in the total group between the frequency of side effects and the tendency to react with an increase in maximum amplitude of the EP when stimulus intensity was increased (i.e., augmenting). The same trend was clear both in the zimelidine group and in the placebo group. Thus the augmenting/reducing response in visual EPs seems to be a predictor of the side effects reported irrespective of the drugs given.
AuthorsL von Knorring, F Johansson
JournalPsychiatry research (Psychiatry Res) Vol. 1 Issue 3 Pg. 225-30 (Dec 1979) ISSN: 0165-1781 [Print] NETHERLANDS
PMID298350 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Pyridines
  • Serotonin Antagonists
  • Zimeldine
  • Brompheniramine
  • Adult
  • Aged
  • Brompheniramine (adverse effects, analogs & derivatives, therapeutic use)
  • Double-Blind Method
  • Evoked Potentials (drug effects)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pain, Intractable (drug therapy, psychology)
  • Photic Stimulation
  • Pyridines (adverse effects)
  • Serotonin Antagonists (adverse effects, therapeutic use)
  • Visual Perception (drug effects)
  • Zimeldine

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: