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Protection against rotavirus-induced gastroenteritis in a murine model by passively acquired gastrointestinal but not circulating antibodies.

Abstract
Newborn mice suckled on dams immunized either orally or parenterally with primate rotavirus SA-11 were protected against diarrhea induced by SA-11 virus challenge. Experimental oral administration of milk from orally immunized dams protected suckling mice against challenge; protective activity was detected both in the anti-rotavirus immunoglobulin A (IgA) and IgG fractions, but IgA was more potent in vivo than IgG. Oral administration of milk from parentally immunized dams also protected suckling mice against challenge; in this case, protective activity was detected in the anti-rotavirus IgG fraction. In newborn mice foster-nursed by seronegative dams, circulating rotavirus-specific antibodies in high titer did not protect mice against oral SA-11 virus challenge. It appears that the most effective rotavirus vaccine will be that which induces an efficient production of antibodies active at the intestinal cell surface.
AuthorsP A Offit, H F Clark
JournalJournal of virology (J Virol) Vol. 54 Issue 1 Pg. 58-64 (Apr 1985) ISSN: 0022-538X [Print] United States
PMID2983120 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Topics
  • Animals
  • Animals, Newborn (immunology)
  • Animals, Suckling (immunology)
  • Colostrum (immunology)
  • Diarrhea, Infantile (immunology, prevention & control)
  • Digestive System (immunology)
  • Disease Models, Animal
  • Gastroenteritis (immunology, prevention & control)
  • Immunization, Passive
  • Mice
  • Milk (immunology)
  • Rotavirus (immunology)
  • Rotavirus Infections (immunology, prevention & control)

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