Abstract |
Newborn mice suckled on dams immunized either orally or parenterally with primate rotavirus SA-11 were protected against diarrhea induced by SA-11 virus challenge. Experimental oral administration of milk from orally immunized dams protected suckling mice against challenge; protective activity was detected both in the anti-rotavirus immunoglobulin A ( IgA) and IgG fractions, but IgA was more potent in vivo than IgG. Oral administration of milk from parentally immunized dams also protected suckling mice against challenge; in this case, protective activity was detected in the anti-rotavirus IgG fraction. In newborn mice foster-nursed by seronegative dams, circulating rotavirus-specific antibodies in high titer did not protect mice against oral SA-11 virus challenge. It appears that the most effective rotavirus vaccine will be that which induces an efficient production of antibodies active at the intestinal cell surface.
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Authors | P A Offit, H F Clark |
Journal | Journal of virology
(J Virol)
Vol. 54
Issue 1
Pg. 58-64
(Apr 1985)
ISSN: 0022-538X [Print] United States |
PMID | 2983120
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Animals
- Animals, Newborn
(immunology)
- Animals, Suckling
(immunology)
- Colostrum
(immunology)
- Diarrhea, Infantile
(immunology, prevention & control)
- Digestive System
(immunology)
- Disease Models, Animal
- Gastroenteritis
(immunology, prevention & control)
- Immunization, Passive
- Mice
- Milk
(immunology)
- Rotavirus
(immunology)
- Rotavirus Infections
(immunology, prevention & control)
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