A malignant cystosarcoma phyllodes with positive estrogen receptor and its heterotransplantation into nude mice.

Abstract

We detected cytosol estrogen receptors in a malignant cystosarcoma phyllodes and succeeded in serial transplantations into athymic nude mice. The tumors of this transplantable strain (MC-3-JCK) have the same histologic features as the original tumors, and retain significant amounts of cytosol estrogen receptors. This strain appears to provide a useful experimental model for the study of biologic and therapeutic aspects of human cystosarcoma phyllodes of the breast.

• Authors: Y Tokuda, M Kubota, Y Ueyama, K Maruo, J Hata, N Tamaoki, T Tajima, T Mitomi
• Journal: Cancer (Cancer) Vol. 55 Issue 2 Pg. 370-4 (Jan 15 1985) ISSN: 0008-543X [Print] United States
• PMID: 2981144 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Estrogen

Topics

• Adult
• Animals
• Breast Neoplasms (analysis, pathology)
• Cytosol (analysis)
• Female
• Humans
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Nude
• Neoplasm Transplantation
• Phyllodes Tumor (analysis, pathology)
• Receptors, Estrogen (analysis)
• Transplantation, Heterologous