Abstract |
The effects of bedtime 70 micrograms and twice daily 35 micrograms doses of enprostil on 24-hour intragastric acidity were investigated in nine duodenal ulcer patients in remission. Median nocturnal acidity decreased significantly by 30% with 35 micrograms twice daily, and by 48% with 70 micrograms at bedtime. In a clinical trial using bedtime dosing, 102 duodenal ulcer patients randomly received either ranitidine 300 mg or enprostil 70 micrograms. More ulcers healed after 4 and 8 weeks treatment with ranitidine than with enprostil (76% ranitidine vs 52% enprostil, at 4 weeks p = 0.0065 and 94% vs 68%, respectively at 8 weeks, P = 0.0007). However, 6 months after cessation of treatment there was no material difference in overall outcome. Despite combining mucosal protection with acid inhibition enprostil treatment conferred no advantage over simple acid inhibition.
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Authors | R P Walt, R E Pounder, C J Hawkey, I A Santana, K W Somerville, R F Logan, R G Long, M J Langman |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 1
Issue 2
Pg. 161-6
(Apr 1987)
ISSN: 0269-2813 [Print] England |
PMID | 2979218
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Aged
- Circadian Rhythm
- Duodenal Ulcer
(drug therapy, physiopathology)
- Enprostil
(therapeutic use)
- Female
- Follow-Up Studies
- Gastric Acid
(metabolism)
- Gastric Acidity Determination
- Humans
- Male
- Middle Aged
- Ranitidine
(therapeutic use)
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