Abstract |
Forty-one patients with advanced ovarian cancer (FIGO stage III or IV) who had relapsed following conventional treatment were treated with long acting depot preparation of D-Trp-6-LH-RH once a month. There were no exclusion criteria and patients of any age or performance status were eligible. Thirty patients continued to progress following therapy. Twenty-six patients died within the first 16 weeks from onset of therapy. Five patients remained stable (SD) on D-Trp-6-LH-RH with no change in tumor size. Six patients had evidence of clinical and/or radiological partial remission (PR) where the tumor size decreased by more than 50%. The remissions in the responding patients were maintained for a mean duration of 10 months (range 6-18 months). Thus 11 patients (6 PR + 5 SD) have had remission or stabilization of disease which has been clinically worthwhile. Clinical benefit of therapy with microcapsules of slow-release D-Trp-6-LH-RH in about 26% of patients is highly encouraging. Treatment with D-Trp-6-LH-RH offers an important non-toxic alternative in patients who do not tolerate chemotherapy or who have progressive disease following chemotherapy.
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Authors | H Parmar, R H Phillips, G Rustin, S L Lightman, A V Schally |
Journal | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
(Biomed Pharmacother)
Vol. 42
Issue 8
Pg. 531-8
( 1988)
ISSN: 0753-3322 [Print] France |
PMID | 2975957
(Publication Type: Journal Article, Review)
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Chemical References |
- Capsules
- Triptorelin Pamoate
- Gonadotropin-Releasing Hormone
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Topics |
- Adult
- Aged
- Capsules
- Female
- Follow-Up Studies
- Gonadotropin-Releasing Hormone
(analogs & derivatives, therapeutic use)
- Humans
- Middle Aged
- Ovarian Neoplasms
(drug therapy, mortality)
- Prospective Studies
- Triptorelin Pamoate
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