Abstract |
Because of its preferential neuroexcitatory effects on the hippocampal neurones kainic acid (KA) is used for inducing partial seizures with a complex symptomatology. In this study the authors investigated the effect of intraperitoneal administration of KA, in doses of 2-16 mg/kg, on the laboratory rat during ontogenesis. The experimental animals were males aged 7, 12, 18, 25 and 90 days. The first signs of an effect in adult rats were automatisms; in young animals, jerks also appeared. The most important automatisms were wet dog shakes, which preponderated in 25-day-old and older animals, whereas in the young rats they consisted chiefly of intensive scratching. Minimal seizures with a motor pattern identical to minimal metrazol seizures were observed in all the age groups and so were generalized tonic-clonic convulsions, which appeared after large doses of KA. The systemic administration of KA is a convenient model of temporal seizures and their progressive generalization and could act as a model for testing broad spectrum antiepileptics.
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Authors | J Velísková, L Velísek, P Mares |
Journal | Physiologia Bohemoslovaca
(Physiol Bohemoslov)
Vol. 37
Issue 5
Pg. 395-405
( 1988)
ISSN: 0369-9463 [Print] Czech Republic |
PMID | 2975798
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Age Factors
- Animals
- Disease Models, Animal
- Epilepsy, Temporal Lobe
(chemically induced, physiopathology)
- Kainic Acid
- Male
- Motor Activity
(drug effects)
- Rats
- Rats, Inbred Strains
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