Pruritic rash with actinic keratosis and impending exfoliation in a patient with hypertension managed with minoxidil.

Abstract

Dermatological toxicity has been reported following initiation of therapy with minoxidil, but no cases have been reported following prolonged use. We report the emergence of an erythematous weeping rash with impending exfoliation three years after the initiation of minoxidil therapy. Minoxidil was withdrawn and the patient responded to therapy with topical corticosteroids. Following minor surgery, the patient was inadvertently rechallenged with minoxidil. Within 24 hours of exposure bullous lesions reappeared in the extremities which again resolved with topical corticosteroids. Dermatological lesions observed on this patient were similar to those reported following acute minoxidil exposure and strongly implicate chronic minoxidil therapy.

• Authors: B H Ackerman, M E Townsend, W Golden, A B Bryan
• Journal: Drug intelligence & clinical pharmacy (Drug Intell Clin Pharm) Vol. 22 Issue 9 Pg. 702-3 (Sep 1988) ISSN: 0012-6578 [Print] United States
• PMID: 2975213 (Publication Type: Case Reports, Journal Article)

Chemical References

• Minoxidil

Topics

• Drug Eruptions (etiology)
• Humans
• Hypertension (drug therapy)
• Keratosis (chemically induced)
• Male
• Middle Aged
• Minoxidil (adverse effects, therapeutic use)
• Pruritus (chemically induced)