Protein content and thyroid hormone release in vitro by differentiated thyroid cancer cells in the presence of estradiol, dehydroepiandrosterone, polypeptidic hormones and pesticides.

Abstract

The reactivity of thyroid cancer cells treated with estradiol (E) and dehydroepiandrosterone (DHA) in the presence of other hormones (TSH, STH, insulin), myopeptide and some pesticides (aminotriazole--ATA, atrazine--ATZ, prometryne--P and ATC) proved to be active in the culture medium. Protein synthesis in sclerosing folliculo-papillary cancer cells under the treatment applied is more markedly inhibited by DHA than by E in the culture medium is compared to the control lots. Tg1 and T3 release into the culture medium under the action of T4 and TSH decreases progressively going from the control to the treated lots, in the presence of E and DHA. STH inhibits Tg1 and T3 secretion in thyroid follicular carcinoma, whether or not E or DHA are present in the culture medium.

• Authors: E Ghinea, L Dumitriu, G Stefanovici, A Pop, A Damian, A Handoca, R Stanciu
• Journal: Endocrinologie (Endocrinologie) 1988 Jul-Sep Vol. 26 Issue 3 Pg. 165-71 ISSN: 0253-1801 [Print] Romania
• PMID: 2975038 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Neoplasm Proteins
• Peptides
• Pesticides
• Thyroid Hormones
• Dehydroepiandrosterone
• Estradiol

Topics

• Dehydroepiandrosterone (pharmacology)
• Estradiol (pharmacology)
• Humans
• Neoplasm Proteins (biosynthesis)
• Peptides (pharmacology)
• Pesticides (pharmacology)
• Thyroid Hormones (metabolism)
• Thyroid Neoplasms (metabolism)
• Tumor Cells, Cultured