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Magnesium aspartate hydrochloride attenuates monocrotaline-induced pulmonary artery hypertension in rats.

Abstract
1. The effect of oral magnesium aspartate hydrochloride on monocrotaline (MCT)-induced pulmonary arterial hypertension was evaluated in rats. 2. A single subcutaneous injection of MCT, a pyrrolizidine alkaloid of plant origin, induces significant morphological changes in pulmonary vessels, pulmonary arterial hypertension and right ventricular hypertrophy in rats by 3 weeks. 3. Two groups of rats (Mg2+ control and Mg2+ + MCT) were started on oral Mg2+ (15.4 g/l magnesium aspartate hydrochloride dissolved in deionized water) 2 weeks before the MCT injection. The rest were given deionized water. At the start of the experiment, the control groups (deionized water and Mg2+) were given normal saline subcutaneously; the other groups (deionized water and Mg2+) were given MCT (60 mg/kg) subcutaneously. 4. Pulmonary artery pressure, right ventricular hypertrophy, lung pathology, organ weights and serum electrolytes were assessed 3 weeks after a single subcutaneous injection of MCT. Seventy-five per cent of the rats treated with MCT and oral Mg2+ (12 out of 16) showed significant reduction in pulmonary arterial hypertension, arterial pathology and right ventricular hypertrophy. 5. Our data indicate that Mg2+ attenuates experimentally induced pulmonary hypertension, possibly either by modulating the intracellular Ca2+ level and/or by directly affecting the pulmonary endothelial cell-smooth muscle cell complex involved in metabolism and maintenance of pulmonary vascular resistance.
AuthorsR Mathew, E S Gloster, B T Altura, B M Altura
JournalClinical science (London, England : 1979) (Clin Sci (Lond)) Vol. 75 Issue 6 Pg. 661-7 (Dec 1988) ISSN: 0143-5221 [Print] England
PMID2974771 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Pyrrolizidine Alkaloids
  • Aspartic Acid
  • Monocrotaline
  • Magnesium
Topics
  • Animals
  • Aspartic Acid (therapeutic use)
  • Blood Pressure (drug effects)
  • Cardiomegaly (chemically induced, prevention & control)
  • Hypertension, Pulmonary (chemically induced, pathology, prevention & control)
  • Magnesium (therapeutic use)
  • Male
  • Monocrotaline
  • Organ Size (drug effects)
  • Plants, Toxic
  • Pulmonary Artery (pathology)
  • Pyrrolizidine Alkaloids
  • Rats
  • Rats, Inbred Strains
  • Senecio

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