Ipsilateral blepharospasm and contralateral hemidystonia and parkinsonism in a patient with a unilateral rostral brainstem-thalamic lesion: structural and functional abnormalities studied with CT, MRI, and PET scanning.

Abstract

A patient developed progressive right hemidystonia in childhood. Subsequently, left-sided blepharospasm, slurred and stuttering speech, and right-sided rigidity and bradykinesia, responsive to dopamine agonists, appeared. Investigation with computed tomography and magnetic resonance imaging (MRI) at age 43 years revealed a left-sided calcified rostral brainstem-thalamic lesion of uncertain aetiology. Although no structural lesion was seen in the striatal regions, L-[18F]-fluorodopa uptake was severely diminished in the left striatum but normal on the right. Dopamine receptor binding identified by [11C]-methylspiperone was in the normal range on both sides.

• Authors: K L Leenders, R S Frackowiak, N Quinn, D Brooks, D Sumner, C D Marsden
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 1 Issue 1 Pg. 51-8 ( 1986) ISSN: 0885-3185 [Print] United States
• PMID: 2973558 (Publication Type: Case Reports, Journal Article)

Chemical References

• Receptors, Dopamine
• Receptors, Dopamine D2

Topics

• Adult
• Blepharospasm (pathology)
• Brain Stem (pathology)
• Corpus Striatum (metabolism)
• Dystonia (pathology)
• Eyelid Diseases (pathology)
• Humans
• Magnetic Resonance Imaging
• Male
• Parkinson Disease (pathology)
• Receptors, Dopamine (metabolism)
• Receptors, Dopamine D2
• Thalamus (pathology)
• Tomography, Emission-Computed
• Tomography, X-Ray Computed