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Spectinomycin disk zone diameter as a predictor of outcome in clinical treatment of gonorrhea.

Abstract
The MICs for 41 Neisseria gonorrhoeae strains from patients receiving spectinomycin treatment were determined by the agar dilution method and compared with the zones of inhibition produced by disks containing 100 micrograms of spectinomycin. Our data demonstrated a good correlation between the two methods. Moreover, a zone of inhibition of less than or equal to 15 mm was a good predictor of clinical treatment failures with spectinomycin.
AuthorsD G McChesney, J W Boslego, W N Khan
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 32 Issue 5 Pg. 775-6 (May 1988) ISSN: 0066-4804 [Print] United States
PMID2969218 (Publication Type: Journal Article)
Chemical References
  • Spectinomycin
Topics
  • Drug Resistance, Microbial
  • Gonorrhea (drug therapy)
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Neisseria gonorrhoeae (drug effects)
  • Prognosis
  • Spectinomycin (pharmacology, therapeutic use)

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