Flare up of joint inflammations induced by cloned helper T cells. Retention of the helper T cells.

Abstract

Joint inflammations were induced in mice by intra articular (ia) injection of cloned helper T cells specific for methylated bovine serum albumin (mBSA) together with mBSA. Local injection of mBSA several weeks after waning of a joint inflammation induced by cloned helper T cells caused a flare up reaction. This indicates that the helper T cells persisted in the joint after the primary inflammation. In the present paper we show that the helper T cells can also persist for some time in a knee joint in the absence of the specific antigen and/or an inflammatory reaction.

• Authors: I S Klasen, R M Ladestein, W B van den Berg, R Benner
• Journal: Agents and actions (Agents Actions) Vol. 23 Issue 1-2 Pg. 69-73 (Feb 1988) ISSN: 0065-4299 [Print] Switzerland
• PMID: 2965496 (Publication Type: Journal Article)

Topics

• Animals
• Arthritis (immunology)
• Clone Cells
• Female
• Mice
• Mice, Inbred C57BL
• T-Lymphocytes, Helper-Inducer (immunology)