Quantitative determination of rimantadine in human plasma and urine by GC-MS.

Abstract

A GC-MS procedure has been developed for the quantitation in plasma and urine of rimantadine, an antiviral drug effective against type A influenza. The assay utilizes selective ion monitoring, methane negative ion chemical ionization (NCI) and stable isotope dilution. Sensitivity to NCI is effected by derivation of rimantadine with pentafluorobenzoyl chloride. The method has been used to quantitate plasma concentrations of rimantadine over a range from 4.2 ng/ml to 416 ng/ml, and urinary concentrations of rimantadine over a range of 21 ng/ml to 2077 ng/ml.

• Authors: E K Fukuda, L C Rodriguez, N Choma, N Keigher, F De Grazia, W A Garland
• Journal: Biomedical & environmental mass spectrometry (Biomed Environ Mass Spectrom) Vol. 14 Issue 10 Pg. 549-53 (Oct 1987) ISSN: 0887-6134 [Print] England
• PMID: 2962655 (Publication Type: Journal Article)

Chemical References

• Rimantadine
• Adamantane

Topics

• Adamantane (analogs & derivatives)
• Chromatography, Gas
• Drug Stability
• Electrochemistry
• Gas Chromatography-Mass Spectrometry
• Humans
• Rimantadine (analysis, blood, urine)