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The effect of rheumatoid factor on the clearance of endogenous immune complexes formed in low-affinity mice during the induction of immune complex disease.

Abstract
Intravenous injection of rheumatoid factor (RF) had a marked effect on the clearance kinetics of immune complexes (IC) formed in vivo during induction of chronic immune complex disease in low-affinity mice. RF resulted in a significant increase in IC level and clearance time in 64% of mice with circulating IC after antigen injection, suggesting that RF may alter the handling of potentially pathogenic IC which localize in the renal capillaries causing glomerulonephritis.
AuthorsM E Devey, D N Hogben
JournalInternational archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 83 Issue 2 Pg. 206-9 ( 1987) ISSN: 0020-5915 [Print] Switzerland
PMID2953686 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigen-Antibody Complex
  • Rheumatoid Factor
Topics
  • Animals
  • Antibody Affinity
  • Antigen-Antibody Complex (immunology)
  • Immune Complex Diseases (immunology)
  • Metabolic Clearance Rate
  • Mice
  • Rheumatoid Factor (immunology)

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