Immunotherapy with RNA in cancer.

Abstract

The effect of I-RNA therapy was studied in a B16 melanoma-C57BL/6J mouse system. After having primary B16 isografts excised, mice receiving syngeneic lymphocytes incubated in vitro with specific guinea pig B16 I-RNA showed significantly improved survival as compared to control mice receiving untreated lymphocytes. This therapeutic effect was tumor specific and RNase sensitive. Significant cytotoxicity against B16 cells in vitro was consistently observed with lymphocytes prepared from B16 I-RNA treated animals, whereas lymphocytes from control animals or those treated with RNase-degraded B16 I-RNA or 3LL I-RNA had no effect. Results suggest that the combination of surgery and immunotherapy with I-RNA may be useful in preventing tumor recurrence in certain patients with cancer.

• Authors: B S Wang, G Steele Jr, S R Onikul, J A Mannick
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 332 Pg. 207-15 ( 1979) ISSN: 0077-8923 [Print] United States
• PMID: 294831 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• RNA
• Ribonucleases

Topics

• Animals
• Cytotoxicity, Immunologic
• Guinea Pigs
• Humans
• Lung Neoplasms (drug therapy, mortality, secondary)
• Lymphocytes (immunology)
• Melanoma (drug therapy)
• Mice
• Mice, Inbred C57BL
• Neoplasms (prevention & control)
• Neoplasms, Experimental (drug therapy)
• RNA (therapeutic use)
• Ribonucleases (pharmacology)