Abstract |
The efficacy of schizophyllan, a beta-1, 3-D-glucan with a beta-1, 6-linked D-glucose residue isolated from Schizophyllum commune Fries, in combination with local radiation therapy was investigated using C3H mouse squamous-cell carcinoma NR-S1. Male C3H/He mice were implanted with 10(5) cells of NR-S1 tumor on day 0. On day 9 after implantation, mice received electron irradiation with a dose of 5,500 rads. Intramuscular injection of SPG (1.0 mg/kg and 5.0 mg/kg) was then started from the day following irradiation and repeated 15 times at one-day intervals. The antitumor effect was measured by the tumor size and survival time. Significant tumor growth suppression and prolongation of life-span were observed in the group given radiation and SPG (5.0 mg/kg) in comparison with the group which received radiation alone. In histopathological examination of irradiated tumor sites, stromal reactions accompanied by a much greater degree of cellular infiltration consisting of mainly lymphocytes were observed in the group given combined radiation and SPG (5.0 mg/kg).
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Authors | T Arika, K Amemiya, S Mochizuki |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 13
Issue 9
Pg. 2841-7
(Sep 1986)
ISSN: 0385-0684 [Print] Japan |
PMID | 2944485
(Publication Type: Journal Article)
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Chemical References |
- Glycosaminoglycans
- Sizofiran
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Topics |
- Animals
- Carcinoma, Squamous Cell
(drug therapy, pathology, radiotherapy, therapy)
- Combined Modality Therapy
- Glycosaminoglycans
(therapeutic use)
- Male
- Mice
- Mice, Inbred C3H
- Radiotherapy Dosage
- Radiotherapy, High-Energy
- Sizofiran
(therapeutic use)
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