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[Combination therapy of radiation and schizophyllan (SPG) in C3H mouse squamous-cell carcinoma NR-S1].

Abstract
The efficacy of schizophyllan, a beta-1, 3-D-glucan with a beta-1, 6-linked D-glucose residue isolated from Schizophyllum commune Fries, in combination with local radiation therapy was investigated using C3H mouse squamous-cell carcinoma NR-S1. Male C3H/He mice were implanted with 10(5) cells of NR-S1 tumor on day 0. On day 9 after implantation, mice received electron irradiation with a dose of 5,500 rads. Intramuscular injection of SPG (1.0 mg/kg and 5.0 mg/kg) was then started from the day following irradiation and repeated 15 times at one-day intervals. The antitumor effect was measured by the tumor size and survival time. Significant tumor growth suppression and prolongation of life-span were observed in the group given radiation and SPG (5.0 mg/kg) in comparison with the group which received radiation alone. In histopathological examination of irradiated tumor sites, stromal reactions accompanied by a much greater degree of cellular infiltration consisting of mainly lymphocytes were observed in the group given combined radiation and SPG (5.0 mg/kg).
AuthorsT Arika, K Amemiya, S Mochizuki
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 13 Issue 9 Pg. 2841-7 (Sep 1986) ISSN: 0385-0684 [Print] Japan
PMID2944485 (Publication Type: Journal Article)
Chemical References
  • Glycosaminoglycans
  • Sizofiran
Topics
  • Animals
  • Carcinoma, Squamous Cell (drug therapy, pathology, radiotherapy, therapy)
  • Combined Modality Therapy
  • Glycosaminoglycans (therapeutic use)
  • Male
  • Mice
  • Mice, Inbred C3H
  • Radiotherapy Dosage
  • Radiotherapy, High-Energy
  • Sizofiran (therapeutic use)

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