[Studies of the antitumor activity and enzymology of 2'-deoxy-5-fluorouridine (FdUrd) derivatives].

The antitumor activity and enzymology of 2'-deoxy-3', 5'-bis-O-(4-methoxyphenoxycarbonyl)-5-fluoro-3-(4-n-Propoxybenz oyl uridine (FF-707) were examined. It was found that stability in small intestine homogenate of FF-707 was higher than that of FF-705 [2'-deoxy-3', 5'-O-diacetyl-5-fluoro-3-(3 methylbenzoyl) uridine]. Reduction of the tumor weight was greater in mice bearing sarcoma-180 and rats bearing Yoshida sarcoma treated with the oral administration of FF-707 than that FF-705. The relationship between the antitumor activity and the inhibition of thymidylate synthase after the oral administration of FF-707 was examined. The extent of the inhibition of thymidylate synthase seemed to be parallel to that of the inhibition of the tumor growth.
AuthorsS Fujii, T Shirasaka
JournalGan no rinsho. Japan journal of cancer clinics (Gan No Rinsho) Vol. 32 Issue 4 Pg. 379-82 (Apr 1986) ISSN: 0021-4949 [Print] JAPAN
PMID2940387 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Floxuridine
  • 2'-deoxy-3',5'-di-O-acetyl-5-fluoro-3-(3-methylbenzoyl)uridine
  • Thymidylate Synthase
  • Animals
  • Antineoplastic Agents (metabolism, pharmacology)
  • Floxuridine (analogs & derivatives, metabolism, pharmacology)
  • Intestine, Small (metabolism)
  • Liver (metabolism)
  • Male
  • Mice
  • Rats
  • Rats, Inbred Strains
  • Sarcoma 180 (pathology)
  • Sarcoma, Experimental (enzymology, pathology)
  • Sarcoma, Yoshida (pathology)
  • Thymidylate Synthase (antagonists & inhibitors)

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