Topical corticosteroid therapy for children: alclometasone dipropionate cream 0.05%.

Abstract

The safety and efficacy of twice-daily applications of alclometasone dipropionate cream 0.05% were evaluated in 39 children with eczema during a three-week open study. Early-morning plasma cortisol levels were monitored at weekly intervals (visits 1, 2, and 3) for six children. For the remaining 33 children, levels were measured at visits 1 and 2 and two weeks later, at visit 4. Improvement in signs and symptoms of erythema, induration, and pruritus and a global response to therapy were determined weekly. Plasma cortisol levels remained within the acceptable normal range of 7 to 25 micrograms/100 ml throughout the study in all 39 children. At the conclusion of treatment, a favorable global response--complete clearing of monitored signs and symptoms--was observed in 28 (72%) children, and marked or moderate improvement was recorded for seven (18%) children.

• Authors: H G Crespi
• Journal: Clinical therapeutics (Clin Ther) Vol. 8 Issue 2 Pg. 203-10 ( 1986) ISSN: 0149-2918 [Print] United States
• PMID: 2938740 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• alclometasone dipropionate
• Hydrocortisone
• Methylprednisolone

Topics

• Administration, Topical
• Anti-Inflammatory Agents (adverse effects, therapeutic use)
• Child
• Child, Preschool
• Dermatitis, Atopic (drug therapy)
• Dermatitis, Seborrheic (drug therapy)
• Diaper Rash (drug therapy)
• Drug Evaluation
• Eczema (blood, drug therapy)
• Erythema (drug therapy)
• Humans
• Hydrocortisone (blood)
• Infant
• Methylprednisolone (administration & dosage, adverse effects, analogs & derivatives)
• Pruritus (drug therapy)