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I.v. sedation for conservative dentistry. A comparison of midazolam and diazepam.

Abstract
Midazolam and the emulsion formulation of diazepam were compared in a cross-over study in 50 patients undergoing out-patient conservative dentistry, with particular regard to sedation and the quality of recovery. Both agents proved effective, but sedation was achieved more rapidly with midazolam (P = 0.001) and was more effective (P less than 0.02). Significantly greater anterograde amnesia for the dental procedure (P less than 0.001) and a more rapid return to normal activities (P less than 0.02) were found with midazolam. Psychometric testing, however, failed to show any objective differences between the treatments. A mean dose of midazolam 0.14 mg kg-1 was required to achieve sedation equating to 0.29 mg kg-1 of diazepam, although there was considerable variation between individual patients.
AuthorsI Barker, D G Butchart, J Gibson, J I Lawson, N Mackenzie
JournalBritish journal of anaesthesia (Br J Anaesth) Vol. 58 Issue 4 Pg. 371-7 (Apr 1986) ISSN: 0007-0912 [Print] England
PMID2937434 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Hypnotics and Sedatives
  • Benzodiazepines
  • Diazepam
  • Midazolam
Topics
  • Adolescent
  • Adult
  • Anesthesia Recovery Period
  • Anesthesia, Dental
  • Anesthesia, Local
  • Anxiety (prevention & control)
  • Benzodiazepines (administration & dosage, pharmacology)
  • Dentistry, Operative
  • Diazepam (administration & dosage, pharmacology)
  • Double-Blind Method
  • Female
  • Humans
  • Hypnotics and Sedatives (administration & dosage, pharmacology)
  • Injections, Intravenous
  • Male
  • Midazolam
  • Middle Aged
  • Psychomotor Performance (drug effects)

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