Abstract |
Midazolam and the emulsion formulation of diazepam were compared in a cross-over study in 50 patients undergoing out-patient conservative dentistry, with particular regard to sedation and the quality of recovery. Both agents proved effective, but sedation was achieved more rapidly with midazolam (P = 0.001) and was more effective (P less than 0.02). Significantly greater anterograde amnesia for the dental procedure (P less than 0.001) and a more rapid return to normal activities (P less than 0.02) were found with midazolam. Psychometric testing, however, failed to show any objective differences between the treatments. A mean dose of midazolam 0.14 mg kg-1 was required to achieve sedation equating to 0.29 mg kg-1 of diazepam, although there was considerable variation between individual patients.
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Authors | I Barker, D G Butchart, J Gibson, J I Lawson, N Mackenzie |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 58
Issue 4
Pg. 371-7
(Apr 1986)
ISSN: 0007-0912 [Print] England |
PMID | 2937434
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Hypnotics and Sedatives
- Benzodiazepines
- Diazepam
- Midazolam
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Topics |
- Adolescent
- Adult
- Anesthesia Recovery Period
- Anesthesia, Dental
- Anesthesia, Local
- Anxiety
(prevention & control)
- Benzodiazepines
(administration & dosage, pharmacology)
- Dentistry, Operative
- Diazepam
(administration & dosage, pharmacology)
- Double-Blind Method
- Female
- Humans
- Hypnotics and Sedatives
(administration & dosage, pharmacology)
- Injections, Intravenous
- Male
- Midazolam
- Middle Aged
- Psychomotor Performance
(drug effects)
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