Dissociation of thrombin generation and platelet secretion in diabetes mellitus.

Abstract

To determine the relationship between thrombin generation and platelet secretion in vivo in diabetes mellitus, we measured simultaneous plasma beta-thromboglobulin (BTG) and fibrinopeptide A (FPA) in 40 insulin-dependent patients without renal disease, and 20 control subjects of similar age. Log mean plasma BTG and FPA were higher in diabetic patients (32.1 vs 23.7 ng/ml, and 2.83 vs 1.49 ng/ml, p less than 0.001 and less than 0.005, respectively). Neither was correlated with plasma glucose or hemoglobin AI. Plasma BTG and FPA were moderately intercorrelated in control subjects (r = +0.36, p = 0.03), but not in diabetic patients (r = +0.09, p = NS). Thus, in diabetes mellitus, thrombin generation as a contributing mechanism to platelet secretion is probably overshadowed by thrombin-independent mechanisms.

• Authors: M H Rosove, J A Berliner, S S Harwig, H J Frank
• Journal: Diabetes research (Edinburgh, Scotland) (Diabetes Res) Vol. 2 Issue 4 Pg. 171-3 (Jul 1985) ISSN: 0265-5985 [Print] Scotland
• PMID: 2935351 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• beta-Thromboglobulin
• Fibrinopeptide A
• Thrombin

Topics

• Adult
• Age Factors
• Aged
• Blood Platelets (metabolism)
• Diabetes Mellitus, Type 1 (blood)
• Female
• Fibrinopeptide A (analysis)
• Humans
• Male
• Middle Aged
• Sex Factors
• Thrombin (biosynthesis)
• beta-Thromboglobulin (analysis)