[Demonstration of glycoprotein antigens associated with stomach tumors].

Abstract

After precipitation of the glycoproteins from gastric tumor tissues by caprylic acid, immunochemical methods were applied to the research of specific gastric tumor antigens; this precipitation process by caprylic acid was less aggressive than the use of urea or proteases. The purification of a fraction associated with tumor tissue has been carried out by affinity chromatography with a specific antiserum immobilized on Sepharose. The obtained fraction contains 4 proteic antigens. One of them is common with all the gastric extracts. Neither CEA, nor alpha-foetoprotein has been detected in this fraction. The corresponding antiserum seems to show a tumor specificity, whereas tissue specificity has to be demonstrated.

• Authors: N Remy-Heintz, J P Bali
• Journal: Comptes rendus des seances de la Societe de biologie et de ses filiales (C R Seances Soc Biol Fil) Vol. 179 Issue 3 Pg. 389-96 ( 1985) ISSN: 0037-9026 [Print] France
• Vernacular Title: Mise en évidence d'antigènes glycoprotéiques associés aux tumeurs de l'estomac.
• PMID: 2935234 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens, Neoplasm
• Glycoproteins
• Immune Sera

Topics

• Antigens, Neoplasm (analysis)
• Electrophoresis, Polyacrylamide Gel
• Glycoproteins (analysis)
• Humans
• Immune Sera
• Immunodiffusion
• Molecular Weight
• Stomach Neoplasms (immunology)