T-cell subsets defined by monoclonal antibodies in monoclonal gammopathy of undetermined significance (MGUS).

Abstract

Peripheral T lymphocytes from 31 patients with monoclonal gammopathy of undetermined significance (MGUS), and from a group of controls of the same age range, were stained using monoclonal antibodies of the OKT series. The absolute number and the percentage of OKT3+ cells did not differ in patients compared with the controls. The percentage and absolute number of T-cell subsets with helper/inducer OKT4+ and suppressor/cytotoxic OKT8+ phenotype were not different from those of the controls, thus the OKT4/OKT8 ratio in the patients with MGUS was normal (1.60 versus 1.57 in normal controls). These results suggest that MGUS is a B-cell disorder without imbalance of peripheral T-cell subsets unlike B-cell malignancies such as multiple myeloma and B-cell chronic lymphocytic leukemia.

• Authors: L Cavanna, M Di Stasi, F Fornari, G Civardi, F Binelli, E Buscarini, L Buscarini
• Journal: Tumori (Tumori) Vol. 71 Issue 6 Pg. 543-6 (Dec 31 1985) ISSN: 0300-8916 [Print] United States
• PMID: 2934880 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal

Topics

• Aged
• Antibodies, Monoclonal
• Female
• Humans
• Lymphoproliferative Disorders (immunology)
• Male
• Middle Aged
• T-Lymphocytes (classification)
• T-Lymphocytes, Helper-Inducer (immunology)
• T-Lymphocytes, Regulatory (immunology)