Amiodarone: pharmacology and antiarrhythmic and adverse effects.

Abstract

Amiodarone is a benzofuran derivative that has been effective for the treatment of both supraventricular and ventricular tachyarrhythmias. It has a large volume of distribution, moderate bioavailability and a long half-life. Its pharmacokinetics are not well understood and its tissue distribution is not typical of a 2-compartment model. Due to ocular, dermatologic, gastrointestinal, neurologic, cardiovascular, thyroid and pulmonary toxicity, amiodarone should be reserved for use in patients with refractory and/or life-threatening arrhythmias.

• Authors: G V Naccarelli, R L Rinkenberger, A H Dougherty, R A Giebel
• Journal: Pharmacotherapy (Pharmacotherapy) 1985 Nov-Dec Vol. 5 Issue 6 Pg. 298-313 ISSN: 0277-0008 [Print] United States
• PMID: 2934688 (Publication Type: Journal Article)

Chemical References

• Benzofurans
• Teratogens
• Amiodarone

Topics

• Action Potentials (drug effects)
• Amiodarone (adverse effects, metabolism, pharmacology, therapeutic use)
• Animals
• Arrhythmias, Cardiac (chemically induced, drug therapy)
• Atrial Fibrillation (drug therapy)
• Benzofurans (therapeutic use)
• Biological Availability
• Cardiomyopathy, Hypertrophic (drug therapy)
• Cardiovascular Diseases (chemically induced)
• Dose-Response Relationship, Drug
• Drug Eruptions (etiology)
• Drug Interactions
• Eye Diseases (chemically induced)
• Gastrointestinal Diseases (chemically induced)
• Heart (drug effects)
• Hemodynamics (drug effects)
• Humans
• Hypothyroidism (chemically induced)
• In Vitro Techniques
• Lung Diseases (chemically induced)
• Membrane Potentials (drug effects)
• Nervous System Diseases (chemically induced)
• Tachycardia, Paroxysmal (drug therapy)
• Teratogens