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Minocycline-associated tooth discoloration in young adults.

Abstract
After observing a patient with adult-onset tooth discoloration coincident with minocycline administration, we retrospectively surveyed a cohort of patients with severe cystic acne during therapeutic trials with isotretinoin. Four of 72 patients who had minocycline therapy during adolescence were found to have minocycline-associated tooth discoloration, which occurred in one case after only four weeks of treatment. Thus, minocycline must be considered as an uncommon cause of tooth staining in adults.
AuthorsS C Poliak, J J DiGiovanna, E G Gross, G Gantt, G L Peck
JournalJAMA (JAMA) 1985 Nov 22-29 Vol. 254 Issue 20 Pg. 2930-2 ISSN: 0098-7484 [Print] United States
PMID2932563 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Tetracyclines
  • Minocycline
Topics
  • Acne Vulgaris (drug therapy, pathology)
  • Adolescent
  • Adult
  • Humans
  • Male
  • Minocycline (adverse effects)
  • Retrospective Studies
  • Skin Pigmentation (drug effects)
  • Tetracyclines (adverse effects)
  • Tooth Discoloration (chemically induced)

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