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Hepatic metastases: liposomal Gd-DTPA-enhanced MR imaging.

Abstract
Liposomal gadolinium diethylenetriaminepentaacetic acid (DTPA) encapsulated within 70- and 400-nm vesicles was tested as a contrast agent for magnetic resonance (MR) imaging of the liver in rats with hepatic metastases. Liposomal Gd-DTPA caused significant improvement in contrast between liver and tumor (P less than .005) on T1-weighted MR images. Smaller 70-nm liposomal Gd-DTPA vesicles caused greater contrast enhancement, reflecting the larger surface-area-to-volume ratio of the smaller vesicles. Liposomal Gd-DTPA-enhanced images permitted significant improvement in metastasis detection by five blinded radiologists (P less than .005). By comparison, free Gd-DTPA without liposomes caused a statistically significant reduction in contrast between tumor and liver and reduced lesion detection (P less than .01). Liposomal Gd-DTPA also resulted in sustained vascular enhancement for 1 hour after administration. The results suggest that paramagnetic liposomes may become a useful MR imaging contrast agent.
AuthorsE C Unger, T Winokur, P MacDougall, J Rosenblum, M Clair, R Gatenby, C Tilcock
JournalRadiology (Radiology) Vol. 171 Issue 1 Pg. 81-5 (Apr 1989) ISSN: 0033-8419 [Print] United States
PMID2928550 (Publication Type: Journal Article)
Chemical References
  • Contrast Media
  • Liposomes
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA
Topics
  • Animals
  • Contrast Media
  • Gadolinium
  • Gadolinium DTPA
  • Liposomes
  • Liver Neoplasms, Experimental (diagnosis)
  • Magnetic Resonance Imaging
  • Organometallic Compounds
  • Pentetic Acid
  • Rats

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