Abstract |
Liposomal gadolinium diethylenetriaminepentaacetic acid ( DTPA) encapsulated within 70- and 400-nm vesicles was tested as a contrast agent for magnetic resonance (MR) imaging of the liver in rats with hepatic metastases. Liposomal Gd-DTPA caused significant improvement in contrast between liver and tumor (P less than .005) on T1-weighted MR images. Smaller 70-nm liposomal Gd-DTPA vesicles caused greater contrast enhancement, reflecting the larger surface-area-to-volume ratio of the smaller vesicles. Liposomal Gd-DTPA-enhanced images permitted significant improvement in metastasis detection by five blinded radiologists (P less than .005). By comparison, free Gd-DTPA without liposomes caused a statistically significant reduction in contrast between tumor and liver and reduced lesion detection (P less than .01). Liposomal Gd-DTPA also resulted in sustained vascular enhancement for 1 hour after administration. The results suggest that paramagnetic liposomes may become a useful MR imaging contrast agent.
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Authors | E C Unger, T Winokur, P MacDougall, J Rosenblum, M Clair, R Gatenby, C Tilcock |
Journal | Radiology
(Radiology)
Vol. 171
Issue 1
Pg. 81-5
(Apr 1989)
ISSN: 0033-8419 [Print] United States |
PMID | 2928550
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- Liposomes
- Organometallic Compounds
- Pentetic Acid
- Gadolinium
- Gadolinium DTPA
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Topics |
- Animals
- Contrast Media
- Gadolinium
- Gadolinium DTPA
- Liposomes
- Liver Neoplasms, Experimental
(diagnosis)
- Magnetic Resonance Imaging
- Organometallic Compounds
- Pentetic Acid
- Rats
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