Treatment of anxiety with ketazolam in elderly patients.

In a multicenter, double-blind trial, 63 elderly patients who had experienced a generalized anxiety disorder for at least one month were randomly assigned to receive 15 mg of ketazolam (n = 31) or placebo (n = 32) daily for 15 days. At the end of this period, if their total scores on the Hamilton Anxiety Rating Scale had decreased by at least 25%, treatment was continued unchanged for a further 15 days. Patients who did not respond to treatment were given an additional 15 mg of ketazolam daily. During the initial 15 days, 83% of the ketazolam-treated patients and 43% of the placebo patients responded to treatment (P < 0.01). During the second 15-day period, the anxiety scores of the ketazolam-treated patients continued to decline significantly, whereas the placebo patients showed no improvement. According to the investigators' assessments of severity of anxiety and patients' ratings of treatment effectiveness, ketazolam was significantly superior to placebo.
AuthorsN Bresolin, G Monza, E Scarpini, G Scarlato, G Straneo, A Martinazzoli, G Benincà, C Cattoni, R De Candia, G Belloni
JournalClinical therapeutics (Clin Ther) Vol. 10 Issue 5 Pg. 536-42 ( 1988) ISSN: 0149-2918 [Print] UNITED STATES
PMID2908803 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Anti-Anxiety Agents
  • Benzodiazepinones
  • Benzodiazepines
  • ketazolam
  • Aged
  • Aged, 80 and over
  • Anti-Anxiety Agents (adverse effects, therapeutic use)
  • Anxiety (drug therapy)
  • Benzodiazepines
  • Benzodiazepinones (adverse effects, therapeutic use)
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Psychiatric Status Rating Scales

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