Abstract |
Fourteen patients with polyarteritis nodosa complicated by histologically confirmed glomerulopathies were included in a prospective multi-center study comparing corticotherapy (group 1, n = 8) with combined cyclophosphamide and steroids (group 2, n = 6). Plasma exchanges were associated on a routine basis. The two groups were comparable apart from initially more severe renal impairment in group 1 (p less than 0.05). Initial control of the disease was obtained in 11 patients (7 from group 1, 4 from group 2) including the patients with oligoanuria. Six patients recovered, 3 had recurrence requiring chronic hemodialysis and 5 patients died from group 1 (p less than 0.05). These preliminary findings suggest that plasma exchange can contribute to control of polyarteritis nodosa with renal complications.
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Authors | B Jarrousse, L Guillevin, S Gie, O Bletry, J Barrier, E Cassuto-Viguier, K S Ang, J F Besancenot, A Sobel |
Journal | Annales de medecine interne
(Ann Med Interne (Paris))
Vol. 139 Suppl 1
Pg. 23-5
( 1988)
ISSN: 0003-410X [Print] France |
Vernacular Title | Pronostic et traitement des glomérulonéphrites de la périartérite noueuse. Place des échanges plasmatiques. |
PMID | 2907849
(Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article, Multicenter Study)
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Chemical References |
- Adrenal Cortex Hormones
- Cyclophosphamide
- Creatinine
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Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Combined Modality Therapy
- Creatinine
(blood)
- Cyclophosphamide
(therapeutic use)
- Glomerulonephritis
(blood, drug therapy, therapy)
- Humans
- Multicenter Studies as Topic
- Plasma Exchange
- Polyarteritis Nodosa
(complications, drug therapy, therapy)
- Prognosis
- Prospective Studies
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