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[Prognosis and treatment of glomerulonephritis of periarteritis nodosa. The role of plasma exchange].

Abstract
Fourteen patients with polyarteritis nodosa complicated by histologically confirmed glomerulopathies were included in a prospective multi-center study comparing corticotherapy (group 1, n = 8) with combined cyclophosphamide and steroids (group 2, n = 6). Plasma exchanges were associated on a routine basis. The two groups were comparable apart from initially more severe renal impairment in group 1 (p less than 0.05). Initial control of the disease was obtained in 11 patients (7 from group 1, 4 from group 2) including the patients with oligoanuria. Six patients recovered, 3 had recurrence requiring chronic hemodialysis and 5 patients died from group 1 (p less than 0.05). These preliminary findings suggest that plasma exchange can contribute to control of polyarteritis nodosa with renal complications.
AuthorsB Jarrousse, L Guillevin, S Gie, O Bletry, J Barrier, E Cassuto-Viguier, K S Ang, J F Besancenot, A Sobel
JournalAnnales de medecine interne (Ann Med Interne (Paris)) Vol. 139 Suppl 1 Pg. 23-5 ( 1988) ISSN: 0003-410X [Print] France
Vernacular TitlePronostic et traitement des glomérulonéphrites de la périartérite noueuse. Place des échanges plasmatiques.
PMID2907849 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article, Multicenter Study)
Chemical References
  • Adrenal Cortex Hormones
  • Cyclophosphamide
  • Creatinine
Topics
  • Adrenal Cortex Hormones (therapeutic use)
  • Combined Modality Therapy
  • Creatinine (blood)
  • Cyclophosphamide (therapeutic use)
  • Glomerulonephritis (blood, drug therapy, therapy)
  • Humans
  • Multicenter Studies as Topic
  • Plasma Exchange
  • Polyarteritis Nodosa (complications, drug therapy, therapy)
  • Prognosis
  • Prospective Studies

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