Cephaloridine resistance in gram-negative bacteria isolated in Scotland.

Abstract

The incidence of cephaloridine resistance (minimum inhibitory concentration, MIC greater than 8 mg L-1) in isolates from urinary tract infections was 45.1% in Glasgow, 22.6% in Dundee and 25.9% in Edinburgh. The incidence of ampicillin resistance (MIC greater than 8 mg L-1) was even higher:- being 45.2% in Dundee and 48.5% in Edinburgh. In Glasgow, the incidence was 71.9% which is the highest proportion of ampicillin resistance reported in the United Kingdom. The cephaloridine resistant strains were examined for beta-lactamase production. Amongst these strains 50.8% produced only a chromosomal beta-lactamase, whereas 47.9% produced beta-lactamases which were potentially plasmid-mediated on the basis of biochemical tests. Only 1% of the resistant strains produced no detectable beta-lactamase.

• Authors: A J Reid, I N Simpson, P B Harper, S G Amyes
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 40 Issue 8 Pg. 571-3 (Aug 1988) ISSN: 0022-3573 [Print] England
• PMID: 2907014 (Publication Type: Journal Article)

Chemical References

• beta-Lactamases
• Cephaloridine

Topics

• Ampicillin Resistance
• Cephaloridine (pharmacology)
• Drug Resistance, Microbial (genetics)
• Gram-Negative Bacteria (drug effects, enzymology, isolation & purification)
• Humans
• Isoelectric Focusing
• Microbial Sensitivity Tests
• Scotland
• Urinary Tract Infections (microbiology)
• beta-Lactamases (genetics, metabolism)