Clinical studies on the use of roxatidine acetate for the treatment of peptic ulcer in Japan.

Abstract

Roxatidine acetate is a novel H2-receptor antagonist with a chemical structure different to the earlier drugs of this type. It is a potent inhibitor of histamine-mediated gastric acid secretion and in animal models is 4 to 6 times as potent as cimetidine. In a multicentre double-blind clinical trial of over 700 patients with gastric or duodenal ulcers roxatidine acetate 75 mg twice daily and cimetidine 200mg four times daily produced endoscopically confirmed and subjective and objective healing rates in excess of 90% for both types of ulcer, with no significant difference between the treatments. Roxatidine acetate's efficacy in stomal ulcer (marginal ulcer) and reflux oesophagitis has been confirmed in non-comparative studies of up to 8 weeks' duration. The overall incidence of adverse reactions in 1623 patients treated with roxatidine acetate 75 mg twice daily was 1.7%, with skin rashes and constipation the most frequently reported side effects.

• Authors: M Inoue
• Journal: Drugs (Drugs) Vol. 35 Suppl 3 Pg. 114-9 ( 1988) ISSN: 0012-6667 [Print] New Zealand
• PMID: 2905239 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Gastrins
• Histamine H2 Antagonists
• Pepsinogens
• Piperidines
• Cimetidine
• Prolactin
• TZU 0460

Topics

• Adult
• Cimetidine (therapeutic use)
• Duodenal Ulcer (drug therapy)
• Female
• Gastrins (blood)
• Histamine H2 Antagonists (adverse effects, therapeutic use)
• Humans
• Japan
• Male
• Middle Aged
• Pepsinogens (blood)
• Peptic Ulcer (drug therapy)
• Piperidines (adverse effects, therapeutic use)
• Prolactin (blood)
• Stomach Ulcer (drug therapy)
• Time Factors