A study of the clinical efficacy of azelastine in patients with extrinsic asthma, and its effect on airway responsiveness.

1. The effect of 4.4 mg azelastine administered orally on airway responsiveness, skin prick testing, daily peak expiratory flow rates and symptoms of asthma was compared with placebo in a 7 week double-blind, parallel group study of 24 patients with extrinsic asthma. The study was in two parts: a 2 week assessment period, during which all patients received placebo tablets but recorded daily peak flow rates (PEFRs) and symptoms, preceding the 7 week double-blind comparison. 2. Azelastine, 4.4 mg, significantly decreased airway responsiveness to histamine compared with placebo both after a single dose (P less than 0.001), and following 7 weeks continuous treatment (P less than 0.02). Airway responsiveness to methacholine was not altered by administration of azelastine compared with placebo. 3. Skin prick test weal diameters to both allergen and histamine were significantly reduced after both a single dose and following 7 weeks continuous therapy treatment with azelastine. 4. There was a significant improvement in both the mean of the morning and the evening peak flow rates recorded during the last week compared with the first week of the study in the group receiving 4.4 mg of azelastine twice daily compared with placebo. Scores for wheeze were significantly reduced during the final 3 weeks of the study in patients receiving azelastine compared both with those receiving placebo and with the first week of the study (P less than 0.05, P less than 0.01). Consumption of inhaled bronchodilators fell significantly during the study in the group receiving azelastine therapy (P less than 0.05); no such fall occurred in the placebo treated patients. 5. A bitter metallic taste was reported by 58% of patients who received azelastine therapy.
AuthorsC A Gould, S Ollier, R Aurich, R J Davies
JournalBritish journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 26 Issue 5 Pg. 515-25 (Nov 1988) ISSN: 0306-5251 [Print] England
PMID2905153 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Histamine H1 Antagonists
  • Phthalazines
  • Pyridazines
  • Albuterol
  • azelastine
  • Adult
  • Albuterol (therapeutic use)
  • Asthma (drug therapy, physiopathology)
  • Bronchial Provocation Tests
  • Double-Blind Method
  • Female
  • Histamine H1 Antagonists (therapeutic use)
  • Humans
  • Hypersensitivity, Immediate
  • Male
  • Middle Aged
  • Peak Expiratory Flow Rate
  • Phthalazines (therapeutic use)
  • Pulmonary Ventilation (drug effects)
  • Pyridazines (therapeutic use)
  • Respiratory Function Tests

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!

Choose Username:
Verify Password:
Enter Code Shown: